PDF Ebook Curing MS: How Science Is Solving the Mysteries of Multiple Sclerosis, by Howard L. Weiner
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Curing MS: How Science Is Solving the Mysteries of Multiple Sclerosis, by Howard L. Weiner
PDF Ebook Curing MS: How Science Is Solving the Mysteries of Multiple Sclerosis, by Howard L. Weiner
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From The New England Journal of Medicine
Scientists, medical researchers, and academic physicians share a fundamental shortcoming: we consistently fail to translate and describe our professional world -- its struggles, its successes, and even its basic workings -- to the general public. In science, this flaw, lamentably, affects the people who direct funding policies, and in medicine it denies knowledge to patients who hope for improvements in and possible cures for their condition. As science rapidly grows more complex and technical, the gap widens between scientific realities and public perceptions of how science works. Indeed, the daily televised diet of medical breakthroughs fails to convey the complexities of medical progress and the difficulties involved in bringing a bench observation to the stage of useful therapy. (Figure) Enter Howard Weiner, a veteran neurologist with decades of experience in medical research on multiple sclerosis, with a monograph on the medical history of such research and the clinical realities of the disease. He draws a rich, fascinating portrait of important failures and successes in this difficult field of medicine. Almost an autobiography, this book is well written and detailed. It also appeals through down-to-earth language that avoids trivialization and places complex biology within the grasp of the interested but uninitiated reader. With mastery, Weiner mixes anecdote with the teaching of biologic, statistical, and medical processes, rendering a living tale that keeps the reader's attention. There is much passion here as the author highlights decades of continuing frustration in the search for causes of the clinically varied and elusive, chronically progressive condition of multiple sclerosis and its many subtypes. This book will be instructive and interesting for patients, their families, and many people with other chronic diseases. The book manages to entertain while drawing a clear picture of the evolving process that drives medical progress, however slowly and ponderously. Few issues remain untouched, from the need for (and danger of) ego as the investigator weathers the many frustrations before the rare successes occur to the stony path from bench observation to bedside use. The tone is inherently optimistic as the book highlights the development and regulatory approval of the small but slowly growing number of drugs approved or already used for the treatment of multiple sclerosis. By and large, the author avoids diving too deeply into science and technology, and he freely and frequently admits that an understanding of the mechanisms involved in multiple sclerosis (and in most other autoimmune diseases) is missing. Much of this book is about clinical trials in a difficult field. The trials suffer from a lack of predictive, surrogate markers of intermediate to long-term outcomes, as well as from a paucity of practical measures of effectiveness, with magnetic resonance imaging a difficult but irreplaceable tool. The author excels at illustrating these points and at emphasizing the need for proper controls, questions, and answers that can be interpreted with confidence in such trials. The title, Curing MS, is bold and misleading, but the author himself corrects the misconception about the likelihood of cures for this disease in the last chapter. The backbone of the book is the "Weiner list" of 21 hypotheses that describe the author's view of multiple sclerosis as a primary autoimmune disease that, possibly, is caused by unknown infectious episodes. Not all of these hypotheses are uniformly acknowledged in the field, but most are in the mainstream; some, such as a strong focus on cytokines, are somewhat dated, though not inappropriately for what is basically a history of the medicine surrounding multiple sclerosis. This book does not attempt to provide a critical assessment of the status of therapy for the disease -- it really does not explain "how science is solving the mysteries of multiple sclerosis," as the subtitle claims -- but it does provide a realistic look at the field, with its challenges, its origins, and the more recent achievements that have been made with a modicum of therapeutic tools. Shawn Winer, Ph.D.Copyright © 2005 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.
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From Booklist
It is estimated that more than 400,000 people in the U.S. have been diagnosed with multiple sclerosis, which affects the nerve fibers in the brain and spinal cord. Moreover, MS--like juvenile diabetes and rheumatoid arthritis, an autoimmune disease--is the number one cause of paralysis in children. No one yet knows what causes the degenerative and progressive malady, but it is believed everyone may have the capability to contract it. Although there have been astounding leaps forward in the creation of treatment options, there is still no cure. Those figures and facts represent but a handful of the topics Harvard neurologist Weiner, founder-director of the Multiple Sclerosis Center at Massachusetts General Hospital, discusses in what ends up as a deconstruction of the last 30 years of his own and general MS research and of experience in treating patients with the puzzling disorder. A noted authority and a pretty good writer, Weiner deftly summarizes what is currently known about treatments and the potential for a cure. Donna ChavezCopyright © American Library Association. All rights reserved
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Product details
Hardcover: 320 pages
Publisher: Crown; 1st edition (May 18, 2004)
Language: English
ISBN-10: 0609609009
ISBN-13: 978-0609609002
Product Dimensions:
6.4 x 1 x 9.5 inches
Shipping Weight: 1.2 pounds (View shipping rates and policies)
Average Customer Review:
3.7 out of 5 stars
29 customer reviews
Amazon Best Sellers Rank:
#2,947,590 in Books (See Top 100 in Books)
When you have a disease like MS. You are always looking for an answer. An answer to why my body has betrayed me and is there hope for a better life. When I saw this book, I was curious. It wasn't until I received it that I saw that this book was published in 2004. I was so disappointed. The author is a medical doctor. I was surprised to see that he discusses using Chemo for those with MS. I have been reading studies from Europe going on right now using Chemo. Dr Weiner was beyond his time. I hope he is still looking for a cure. The book has a lot of information in it but I felt it is more geared more toward physicans rather then the patient.
Well it is an interesting read, but it shows no cure. It does show the history on how medicine has been looking for cures. They developed therapies, but only therapies that can get you a little better or remission if caught early. And it sees there is a stage for MS that doesn't respond at all to any therapy. So in the end, this was a sad read, rather than a hopeful read. Not a bad book to see what MS stages and therapies are if your doctor just doesn't mention this all to you if you have MS.
Excellent book for understanding the MS disease. Answers a lot of questions.
This book never once mentioned Word One about the impact of diet and nutrition in treating Multiple Schlerosis. Not Once!I am a firm believer, (based on my own personal experiences with changing my diet and the PROFOUND impact it has had on managing my MS and vastly improving my physical, mental and emotional well being), that diet and nutrition play a pivotal role in treating MS and turning around the outcomes of patients suffering from the ravages of this disease. This book focused solely on medical treatments, and never once made mention about how the foods we put into our mouths can greatly affect our health, ....both good and bad.My soon-to-be former MS doctor can object all he wants to about this point of diet's impact on medical outcomes, but I strongly defend my stance on the dietary choices I've made to treat this disease, versus injecting my body with dangerous chemicals that do NOTHING to treat the disease....only serving to {sometimes} stop further disease progression.So any book, no matter how old it is, that does not mention or discuss such crucially important factors as the impact of diet and nutrition on medical outcomes, is not worth the cost of the paper it took to print the book!
This is an awesome book. I highly recommend it. I'm glad to be diagnosed in this day and age as there are now so many options available.
Very accessible history of the research and advances in the treatment of MS over the past several decades. Weiner has a straightforward style that explains complex topics by relating them to the symptoms and experiences of his patients. I found it very informative in learning about the disease after my own diagnosis and how the different treatments my doctors recommended work.
Want to know why your MS meds cost so much. Take a look into the world of MS research. I read this book five years ago after initial diagnosis and was thrilled to re-read the updated version.
I have had MS for over 25 years and read a lot of books and articles. Thiswas quite informative. A lot of information, personal stories, very readable. The medical community is still trying very hard to find an answer to this crazy disease.
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